Last data update: May 06, 2024. (Total: 46732 publications since 2009)
Records 1-7 (of 7 Records) |
Query Trace: Mathias PI[original query] |
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Survey of guidelines and current practices for safe handling of antineoplastic and other hazardous drugs used in 24 countries
Mathias PI , MacKenzie BA , Toennis CA , Connor TH . J Oncol Pharm Pract 2017 25 (1) 1078155217726160 Purpose A survey of guidelines and current practices was conducted to examine the safe handling procedures for antineoplastic and other hazardous drugs that are used in 24 countries including the Americas, Europe, the Mideast, Far East, and Australia. Methods Subject experts were asked to complete a brief survey regarding safe handling guidelines and practices for hazardous drugs in their countries. Questions addressed practices for handling monoclonal antibodies, the use of closed-system transfer devices, medical surveillance practices, and measurements of compliance with existing guidelines. Results Responses from 37 subject experts representing 24 countries revealed considerable variation in the content and scope of safe handling guidelines and pharmacy practices among the participating countries. Guidelines in the majority of countries used the term "cytotoxics," while others referred to "hazardous" or "antineoplastic" drugs. The International Society of Oncology Pharmacy Practice standard was cited by six countries, and five cited the National Institute for Occupational Safety and Health Alert. Others cited international guidelines other than International Society of Oncology Pharmacy Practice, or they have created their own guidelines. Approximately half reported that their guidelines were mandatory under federal, state, or provincial legislation. Only 11 countries reported that monoclonal antibodies were covered in their guidelines. Closed-system drug-transfer devices are widely used, but were not specifically recommended in four countries, while one country required their use. Medical surveillance programs are in place in 20 countries, but only in The Netherlands is surveillance mandatory. Nine countries reported that they have completed recent updates or revisions of guidelines, and the measures for their adoption have been initiated. Conclusions Although the overall goals in the participating countries were similar, the approaches taken to assure safe handling of hazardous drugs varied considerably in some cases. |
A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers
Mathias PI , Connor TH , B'Hymer C . J Chromatogr B Analyt Technol Biomed Life Sci 2017 1060 316-324 This review describes published high performance liquid chromatography/mass spectrometry (HPLC-MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC-MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC-MS methods are presented, as well as future trends and limitations in this area of research. |
Mercapturic acids: recent advances in their determination by liquid chromatography/mass spectrometry and their use in toxicant metabolism studies and in occupational and environmental exposure studies
Mathias PI , B'Hymer C . Biomarkers 2016 21 (4) 1-23 This review describes recent selected HPLC/MS methods for the determination of urinary mercapturates that are useful as noninvasive biomarkers in characterizing human exposure to electrophilic industrial chemicals in occupational and environmental studies. High-performance liquid chromatography/mass spectrometry is a sensitive and specific method for analysis of small molecules found in biological fluids. In this review, recent selected mercapturate quantification methods are summarized and specific cases are presented. The biological formation of mercapturates is introduced and their use as indicators of metabolic processing of reactive toxicants is discussed, as well as future trends and limitations in this area of research. |
A survey of liquid chromatographic-mass spectrometric analysis of mercapturic acid biomarkers in occupational and environmental exposure monitoring
Mathias PI , B'Hymer C . J Chromatogr B Analyt Technol Biomed Life Sci 2014 964 136-45 High-performance liquid chromatography/mass spectrometry (HPLC/MS) is sensitive and specific for targeted quantitative analysis and is readily utilized for small molecules from biological matrices. This brief review describes recent selected HPLC/MS methods for the determination of urinary mercapturic acids (mercapturates) which are useful as biomarkers in characterizing human exposure to electrophilic industrial chemicals in occupational and environmental studies. Electrophilic compounds owing to their reactivity are used in chemical and industrial processes. They are present in industrial emissions, are combustion products of fossil fuels, and are components in tobacco smoke. Their presence in both the industrial and general environments are of concern for human and environmental health. Urinary mercapturates which are the products of metabolic detoxification of reactive chemicals provide a non-invasive tool to investigate human exposure to electrophilic toxicants. Selected recent mercapturate quantification methods are summarized and specific cases are presented. The biological formation of mercapturates is introduced and their use as biomarkers of metabolic processing of electrophilic compounds is discussed. Also, the use of liquid chromatography/tandem mass spectrometry in simultaneous determinations of the mercapturates of multiple parent compounds in a single determination is considered, as well as future trends and limitations in this area of research. |
Detection of DNA damage in workers exposed to JP-8 jet fuel
Krieg Jr EF , Mathias PI , Toennis CA , Clark JC , Marlow KL , B'Hymer C , Singh NP , Gibson RL , Butler MA . Mutat Res 2012 747 (2) 218-27 The genotoxicity of jet propulsion fuel 8 (JP-8) was assessed in the leukocytes of archived blood specimens from U.S. Air Force personnel using the comet assay. No differences in mean comet assay measurements were found between low, moderate, and high exposure groups before or after a 4hour work shift. Before the work shift, mean tail DNA and mean tail (Olive) moment increased as the concentration of benzene measured in end-exhaled breath increased, indicating that prior environmental or work-related exposures to benzene produced DNA damage. The number of cells with highly damaged DNA decreased as the pre-shift benzene concentration in breath increased. It is not clear why the decrease is occurring. Mean tail DNA and mean tail (Olive) moment decreased as the concentrations of benzene and naphthalene measured in breath immediately after the work shift increased. These inverse relationships may reflect a slower rate of absorption or a faster rate of expiration of benzene in the lung. The number of cells with highly damaged DNA increased as the concentration of urinary (2-methoxyethoxy)acetic acid (MEAA) increased. This relationship was not seen in urinary MEAA adjusted for creatinine. MEAA is a metabolite of the deicing agent 2-(2-methoxyethoxy)ethanol contained in JP-8. MEAA or a component of JP-8 correlated with MEAA may have a toxic effect on DNA. |
Comparison and evaluation of urinary biomarkers for occupational exposure to spray adhesives containing 1- bromopropane
Mathias PI , Cheever KL , Hanley KW , Marlow KL , Johnson BC , B'Hymer C . Toxicol Mech Methods 2012 22 (7) 526-32 Three metabolites of 1-bromopropane (1-BP) were measured in urine samples collected from 30 workers exposed to 1-BP at two facilities making furniture seat cushions and evaluated for use as biomarkers of exposure. The mercapturic acid metabolite,N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys), 3-bromopropionic acid (3-BPA), and bromide ion levels (Br(-)) were quantitated for this evaluation. The high exposure group consisted of 13 workers employed as adhesive sprayers who assembled foam cushions using 1-BP containing spray adhesives and the low exposure group consisted of 17 non-sprayers, who worked in various jobs without spraying adhesives. All workers' urine voids were collected over the same 48 hour period at work, and at home before bedtime, and upon awakening. Urinary AcPrCys and Br(-)levels were elevated in the sprayers compared to that ofnon-sprayers. Following HPLC-MS/MS analysis of mercapturic acid metabolite levels, 50 urine samples having the highest levels of AcPrCys were analyzed for 3-BPA. No 3-BPA was detected in any of the samples. The data collected from this study demonstrate that ACPrCys and Br(-) are effective biomarkers of 1-BP exposure, but 3-BPA is not. |
Evaluation of surface-enhanced laser desorption time-of-flight mass spectroscopy in the development of biomarkers of occupational acrylamide exposure
Mathias PI , Cheever KL . Am Lab 2011 43 (11) 34-+ Surface-enhanced laser desorption time-of-flight mass spectroscopy (SELDI-TOF-MS) is a bioanalytical technique used for the rapid examination of intact protein or protein mixtures to exploit the biochemical or biophysical characteristics of intact molecules to separate a complex protein mixture or isolate specific protein classes. Surface-enhanced laser desorption time-of-flight mass spectroscopy allows for rapid examination of protein components of body fluids or cell lysates without extensive extraction or preparative measures. The levels and composition of proteins found in blood and urine may change after exposure to toxic agents.1,2 Such potential changes make the proteins found in these easily obtained fluids a desirable source of new or altered proteins that indicate toxic exposure. This article describes the use of SELDI-TOF to examine urinary proteins or hemoglobin present in erythrocyte lysates. | Acrylamide is a widely used industrial chemical intermediate with many applications,3 such as a polymerizing agent in grouts and in the preparation of laboratory gels for protein and nucleic acid electrophoresis. Low levels of acrylamide present in baked, fried, and roasted foods and in tobacco smoke are common sources of human exposure.4 Acrylamide is a potent neurotoxin5 and is a probable human carcinogen that makes exposure a concern for human health.6 |
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